Mario Puzzle Games is a collative group of numerous puzzle spin-off games based on the Mario series. The most prominent and successful games fall under the Dr. Mario series, where Mario dresses up like a doctor to defeat viruses with megavitamins. The first game to make Mario enter the puzzle genre was the arcade game VS. Wrecking Crew which was released in 1984, then for the Nintendo Entertainment System a year later. As of December 2019, the Dr. Mario series has sold 11.49 million copies worldwide. Combining all the puzzle games, Mario Puzzle Games have sold at least 13.146 million copies worldwide.
|1994||SNES||Tetris & Dr. Mario||Unknown|
|2001||N64||Dr. Mario 64||0.34*|||
|2003||GCN||Nintendo Puzzle Collection||0.110|||
|2004||GBA||Classic NES Series: Dr. Mario||0.56*|||
|2005||GBA||Dr. Mario & Puzzle League||0.29*|||
|2008||WiiWare||Dr. Mario Online Rx||Unknown|
|DSiWare||Dr. Mario Express||Unknown|
|2013||Wii U eshop||Dr. Luigi||Unknown|
|2015||3DS eshop||Dr. Mario: Miracle Cure||Unknown|
|2019||Mobile||Dr. Mario World||Free|
Other Mario Puzzle Games
|1993||SNES||Mario & Wario||Unknown|
|SNES||Mario's Super Picross||0.250|||
|1998||SNES||Wrecking Crew '98||Unknown|
|2004||GBA||Famicom Mini 14: Wrecking Crew||0.066|||
|2015||3DS||Puzzle & Dragons: Super Mario Bros. Edition||0.54*|||
- * include VGChartz numbers
- JPN currently only Japanese sales number available
- Dr. Mario was also released for the arcade machines VS. System and PlayChoice-10 in 1990.
- Tetris & Dr. Mario was only released in North America and Europe.
- Dr. Mario 64 was only released in North America.
- Nintendo Puzzle Collection, which contains a port of Dr. Mario 64 was only released in Japan.
- Wrecking Crew was released as VS. Wrecking Crew for the arcade VS. System one year before its release on the NES.
- Mario & Wario, Mario's Super Picross, Picross 2, Wrecking Crew '98, and Famicom Mini 14: Wrecking Crew were only released in Japan.